Startups : Innovation + Job News

When River Wards Café founder Joe Livewell gets on the phone with Flying Kite, his need to pause the conversation is a pretty good indicator of where the business is now, and where it’s headed.

Livewell works seven days a week at the café, which opened in March. There are two other staffers on the team so far, but he was behind the counter himself during our interview and had to put down the phone for a rush of customers.

"I think I just sold everything on the menu," he says of the variety of things his customers just bought.

Livewell grew up in Fishtown. The La Salle University alum started his career in finance, working as a high-yield bond trader, and then transitioned to a job consulting for a software company in San Francisco.

But owning his own business has always been at the back of his mind.

"I didn’t know how to transition from career to business owner," he recalls, "It is a pretty intimidating jump when I didn’t know which levers to pull to make it happen financially...I got this really strong feeling one Monday morning that I didn’t want to do [the software job] anymore."

He first branched out into working for himself with a kids’ clothing line that didn’t prove profitable, but it was the bridge he needed to think seriously about a more independent career.

"It got me living differently," he says. "I was flexible; I didn’t have a nine-to-five to go to…Basically, I started making connections and relationships that would allow me to [have my own business]."

Back in Philly, he began working for ReAnimator Coffee as a wholesale bagger in their roasting facility; he also worked a stint at Fishtown vintage retailer Jinxed.

ReAnimator was "a big influence on my coffee practice," he says of adding a passion for the brew to his existing expertise in finance and customer service. His first real look at opening a café of his own came when he bumped into real estate developer and future business partner Laurence McKnight (a family friend) about two years ago.

McKnight was developing a property on Richmond Street in Port Richmond, and there was a vacancy at 3118. They talked about doing a coffee shop. Work on the 800-square-foot space, which seats about 25, really ramped up in winter 2016 with woodwork from Fishtown’s Philadelphia Woodcraft Company.

Now River Wards Café serves ReAnimator’s Keystone Blend, pastries from Au Fournil and soft pretzels from Center City Pretzel Co.

Livewell says his customers enjoy the personalized experience they get at the café.

"We’re very open talking about what we’re serving and engaging the neighborhood," he says. He attributes much of his success so far to the active support of the community. "We’re doing well. Every day new customers come in, and a lot of times they’re so excited." Five months after opening, people are still saying "thank you for coming to Port Richmond. And I think that’s going to continue as businesses come to the street."

River Wards Café opens at 7 a.m. on weekdays and 8 a.m. on Saturdays and Sundays. It closes at 3 p.m.

Writer: Alaina Mabaso
Source: Joe Livewell, River Wards Café 

As a young fashion designer out of Penn State, Scott Latham learned how hard it is to reach the marketplace. Now he is founder and CEO of Colabination, a site he describes as an Etsy for independent streetwear apparel brands.
 
Latham launched the company less than a year ago, and found a welcoming home at the University City Science Center’s Quorum. Today, Colabination employs 16, offers more than 200 hard-to-find streetwear labels from around the world, and recently moved into its own space in Fishtown.
 
The enterprise boasts a three-member fashion buying team -- they scour the globe looking for cool independent brands that represent quality and value (most items are under $100), and have "a great story to tell," which often means a socially or environmentally conscious mission, a unique aesthetic or intriguing origin tale.
 
The site charges a 30 percent commission for every sale in exchange for its web-optimized sales platform and sophisticated marketing. The brands do their own order fulfillment.
 
Latham is effusive in his praise for the help he got at Quorum. Free workspace alone was huge for the startup, and they benefited mightily from the camaraderie and networking opportunities. He recruited his chief technology officer at Quorum. Upstairs neighbors Nick Siciliano and Ben Pascal, founders of Invisible Sentinel, became trusted mentors. And he still can’t get over the day last fall when Science Center President Steve Tang introduced him to "Jim," who turned out to be then Mayor-Elect Jim Kenney.
 
"Quorum was a huge stepping stone for us," he enthuses.
 
For now, Colabination is focused on streetwear for millennials, but Latham hopes to expand to a broader selection of men's and women’s apparel. The company is testing its XCollection, now in beta, which allows customers to shop their personally curated brands with an algorithm that reacts to their preferences.  
 
The goal is to be "a destination to discover new brands for all types of products and shop them on demand," he concludes. "A modern day mall.”

WRITER IN RESIDENCE is a partnership between the University City Science Center and Flying Kite Media that embeds a reporter on-site at 3711 Market Street. The resulting coverage will provide an inside look at the most intriguing companies, discoveries and technological innovations coming out of this essential Philadelphia institution.
 

About a year and a half ago, local startup MilkCrate began an incubator residency through Project Liberty. This came after a potent mix of bartering, bootstrapping and crowdfunding helped to launch the sustainable-living app. Now the company is ready to add a major new level to their platform that goes beyond individual users.
 
The free MilkCrate app officially launched in early 2015 as a resource for people who want an easy way to connect to socially and environmentally conscious businesses and services. It has since expanded beyond Philly to Denver, Boston and Asheville. Co-founder and CEO Morgan Berman, who earned a master’s degree in sustainable design from Philadelphia University, was pleased to see traction from the original concept, but the team quickly realized that more was on the table.
 
"We actually took a pretty radical approach to both our business model and our product," she says of the revamp, launching this month.
 
MilkCrate for Communities isn’t replacing the original free app -- it’s an add-on service that companies, universities and other enterprises will be able to purchase and extend as a perk to their employees, students or residents. It will also let buyers quantify and collect data on real-life social- and eco-conscious practices within their organizations, which can be harnessed both for external branding and marketing as well as internal messaging, all while encouraging sustainable living.
 
The company realizes that app platforms aimed at boosting sustainable practices at large institutions or companies already exist, but MilkCrate has a major edge because they already have a comprehensive localized directory and calendar within their existing product.  
 
Berman says MilkCrate for Communities is a premium, private "game-ified" social experience that clients can tailor for their users. Members of participating groups can download the free app and, unlike in the public version, log in and begin earning points for things like checking into a farm-to-table restaurant or fair-trade coffee shop, signing up for a composting service or CSA, or volunteering.
 
Participating companies and schools can use MilkCrate to tabulate the eco-friendly and socially conscious steps users make, and incentivize them with quarterly or semester-based rewards.
 
The first official buyer of the MilkCrate for Communities platform is Berman’s own alma mater, Philadelphia University, which will launch the experience for students and faculty this summer. Other clients are already in the pipeline, including the co-working provider Benjamin’s Desk, home to MilkCrate’s offices. Berman says a customized pilot product for Comcast is also in the works.
 
"We are looking for more corporate and academic clients that want to be part of the big launch this summer,"she adds. Anyone who wants to bring a demo of MilkCrate for Communities to their campus or office can get in touch.
 
Writer: Alaina Mabaso
Source: Morgan Berman, MilkCrate 

Even for farm-to-table chefs who are invested in serving humanely and sustainably sourced meat, connecting to the right supplier is difficult.
 
"It’s just a really broken chain," explains former Kensington Quarters (KQ) head butcher Heather Marold Thomason. Many chefs and home cooks want to minimize waste and know exactly where their meat comes from, "but it’s not easy for anybody to use whole animals."
 
Enter Thomason's new company Primal Supply Meats.
 
Over the last year, the idea for the startup evolved as she got to know her customers at KQ’s retail meat counter. Word was spreading around the city about the quality of the locally sourced meat for sale at this Frankford Avenue retail/restaurant hybrid.
 
"More and more people were approaching us," she recalls. "We had a really awesome relationship with people in the Fishtown area who were our everyday customers." She also began to notice shoppers coming from other parts of town -- from South Philly to Mt. Airy -- saying they wished KQ delivered or had other locations. "I also had a lot of chefs approaching me, saying, 'How are you getting this meat? Can you help me?'"
 
She realized there were farm-to-table chefs all over the city who aren’t able to take a whole animal into their kitchen, but didn't want pre-cut frozen meat either.
 
Primal Supply Meats, while not a retail counter like KQ’s, bridges that gap, acting as a liaison between farmers and chefs. The entire butchered animal is used, but shared among as many as three or four different clients asking for different cuts.
  
"I think that our customers have actually been receptive to what we’re doing and their responsibility as customers," says Thomason. With a fresh, whole-animal model at the KQ counter, part of her job was guiding customers to what was available that would also suit their tastes and needs. "Our customers were super-receptive to that."
 
That’s part of why she has high hopes for the CSA-like subscription model Primal will launch in a few weeks (those interested can visit the website). Individuals or families will be able to purchase meat packages on a rolling month-to-month basis, and have confidence in knowing where their meat is coming from.
 
While she hopes Primal will eventually gain its own space, it’s currently operating in West Philly via a partnership with the new FDA-certified facility 1732 Meats. For trucking and cold storage, Primal is partnering with North Philly’s Common Market.
 
This summer, things are still getting off the ground -- Thomason is visiting farmers one-on-one, learning both sides of the business.

"We’re working on getting all the infrastructure in place, making sure our supply chain works and our production processes are solid," she says. "[That way] we can make sure we’re ready to meet demand as it comes."
 
Writer: Alaina Mabaso
Source: Heather Marold Thomason, Primal Supply Meats

Quantitative Radiology Solutions is the latest company to hang its shingle at the University City Science Center's Port Business Incubator. 

By taking up residency at the Port, Quantitative gains access to an extensive network of resources to grow its business. Quantitative is also a participant in the Phase I Ventures Program, which allows early-stage companies to test their business feasibility in a low-risk environment. Quantitative received $213,000 in direct financing from P1V and additional grants from the National Institutes of Health and the National Science Foundation.

The startup is developing a technology that promises to disrupt radiation therapy and treatment for cancer patients. We asked Joe Camaratta, Quantitative's president and CEO to tell us more.

What is your big idea? 

Quantitative Radiology Solutions helps physicians make optimal treatment decisions through analysis of medical images. Our initial product, Automatic Anatomy Recognition (AAR), supports recognition, delineation and quantification of anatomical objects and diseased tissues in multiple body regions using CT, PET/CT and MR images. 

Unlike existing automatic segmentation approaches that work on only three to five objects in a specific body region and require an unacceptable number of manual adjustments, AAR recognizes and delineates all anatomical structures in a given body region accurately and efficiently.  

What is your origin tale? 

The company was [founded by] Drs. Jayaram Udupa (computer science) and Drew Torigian (radiology) at the University of Pennsylvania.

Dr. Udupa was developing a novel image segmentation algorithm that used hierarchical modeling and machine learning techniques for object identification and delineation. Dr. Torigian, who focuses on quantification of disorders using computer-assisted techniques, applied the algorithm in body fat quantification and obstructive sleep apnea to demonstrate its usefulness in radiology.  

Dr. Udupa presented the new approach during a seminar to physicians and physicists from the Department of Radiation Oncology, and was approached by Drs. Peter Bloch (medical physics) and Charles Simone (radiation oncology) about its application in radiotherapy planning. Drs. Udupa and Torigian contacted the Penn Center for Innovation and created Quantitative Radiology Solutions as part of the UPstart program to commercialize technology. I joined as president and CEO to lead these efforts. 

What is ahead for Quantitative Radiology Solutions?

Our initial application area is radiation therapy planning. We believe there are applications of our technology in medical oncology to help assess tumor response to therapeutic interventions. There are also potential applications in surgical planning and 3-D printing using medical images. 

Why does the marketplace need your company? 

The global market for medical imaging is forecasted to reach $50 billion by 2020, and advanced modalities such as CT, MR and molecular imaging will account for 50 percent of that market. The rise in the number of imaging exams and number of images per exams necessitates new approaches to augment a physician’s ability to effectively evaluate exam results in a timely manner. A quantitative approach to medical imaging interpretation can improve early disease diagnosis, standardize assessment of disease response to treatment, and enable the discovery of new disease biomarkers. 

What is your elevator speech? 

We combine 75 years of expertise in clinical imaging, computational theory and algorithm development, and product development and commercialization [experience] from industry-leading organizations in medical imaging. When applied to the field of radiation therapy planning, our approach enables a robust standalone software solution that significantly improves the speed and accuracy of imaging contouring to support initial treatment planning and adaptive radiotherapy.

WRITER IN RESIDENCE is a partnership between the University City Science Center and Flying Kite Media that embeds a reporter on-site at 3711 Market Street. The resulting coverage will provide an inside look at the most intriguing companies, discoveries and technological innovations coming out of this essential Philadelphia institution.
 

Last week, we looked at what Pennovation Works Director of Development Paul Sehnert calls "a real differentiator" for the new campus’s flagship building: wet labs for small local start-ups.

But the wet labs aren’t the only assets that might catch the eye of Philly entrepreneurs in need of space. The ground floor of the Pennovation Center (slated to open later this summer on the banks of the Schuylkill) features twelve units the designers have dubbed "inventor garages," and they're available for lease.

These 500-square-foot spaces are pretty simple: they’re finished and painted on the inside, and have a small complement of moveable (or removable) desks and chairs that can accommodate three or four people.

"They’re super-cool," explains Sehnert. "They actually have a garage-style door opening onto a small plaza, and a glass and wood door on the inside. It’s a fun and useful feature, but it’s about more than just function. We all know that Apple and Hewlett Packard started in a garage. That’s why we called [them] 'inventor garages.'"

Companies who lease the spaces (as of mid-June, seven were spoken for, with five still available) will also be part of the larger community at the Pennovation Center and be entitled to six hours of meeting space outside the garage each month.

But "you’ve got your own clubhouse," Sehnert continues. "You retreat to your garage and on a pleasant day, you can open the garage door and get daylight. You can actually use the garage door if you have equipment that you load or have materials that you’re moving in and out.”

Uses for the garages might include a combo of storage and work space, light duty fabrication, space for programmers or coders to get working, or simply a welcoming, utilitarian spot for folks who need to roll in a whiteboard and brainstorm.

And as with the wet labs, the inventor garages are designed as a launch pad -- not a permanent home -- for the companies who land there (some of whom may progress into larger lab space Pennovation is developing). The garages will have lease terms of one year, though this is negotiable.

“We want you to start your company and then graduate," insists Sehnert. "We want you to face the world and move on."

Writer: Alaina Mabaso
Source: Paul Sehnert, Pennovation Works

The One Health Company is sending clinical trials to the dogs. And cats. And horses.

The startup, a participant in the University City Science Center Digital Health Accelerator, offers a new model of contract research by conducting pre-clinical trials on already ill patients: aka peoples' pets.

The science behind the idea is strong, says founder and CEO Benjamin Lewis. Disease induced in lab animals is often a poor proxy for natural human disease. Currently, 92 percent of animal cancer trials fail in people.

But pets, many of them genetically similar to humans -- and who typically share our environment -- are ideal proxies for 350 natural human diseases. Lhasa Apsos and male cats develop bladder stones. Poodles are frequently afflicted by cataracts. Golden Retrievers get Non-Hodgkin's Lymphoma. Horses suffer from osteoarthritis.

The approach, says Lewis, is also far more humane that inducing disease in lab animals.

"We have so many sick animals," he says. "Why create more so we can kill them and study them?"

One Health operates out of 350 specialty animal hospitals across the United States. Founded only this year, it already has 450,000 animals in its database and expects to have millions by the end of the year.

The company is currently conducting two trials. Details are proprietary, but their testing is mostly in cancer and endocrine diseases. One Health will test only for efficacy of pharmaceuticals, biologics, injectables, large molecules, medical devices and diagnostics. Testing for toxicology or safety is far too risky for client-owned pets.

Animals enrolled in One Health clinical trials remain with their owners and stay at home for care, returning to the hospital for evaluation by veterinary specialists, rather than being shipped to a lab or a longterm veterinary clinic. At the conclusion of the study, the hope is that the animal is cured or its symptoms ameliorated.

"I’m not asking anyone to do anything I haven’t done with my own pet," adds Lewis. One of his three rescue dogs -- Lulo, a Doberman -- participated in an osteosarcoma trial three years ago. Lulo lost a leg, but is going strong three years later. The prognosis is usually just three months.
 
WRITER IN RESIDENCE is a partnership between the University City Science Center and Flying Kite Media that embeds a reporter on-site at 3711 Market Street. The resulting coverage will provide an inside look at the most intriguing companies, discoveries and technological innovations coming out of this essential Philadelphia institution.
 

For a small startup ready to research or develop chemical or biological innovations, finding lab space can be a challenge. Dry labs, which host technological or computer studies, or studies in fields like psychology, aren’t hard to outfit and rent. But wet labs -- featuring the equipment and safety measures needed to work with chemical and biological materials -- are another story.

This summer, labs at the soon-to-open Pennovation Center will help to change that for a select group of local companies.

About a year and a half ago, we covered the groundbreaking at University of Pennsylvania’s new 23-acre Pennovations Works campus on the south bank of the Schuylkill River: the three-story, 58,000-square-foot Pennovation Center at 34th Street and Gray’s Ferry Avenue will be the centerpiece.

The Center is slated to open this August. Its second floor will feature wet lab space available for lease to local startups.

"Wet labs are pretty unusual commodities" for this market, explains Paul Sehnert, director of development for Pennovation Works. "They’re usually built on a customized basis for companies under a long-term lease… If you're a startup company, it’s really a top dilemma. You need a space to work out of, but you can’t sign a lease and find a lab without making a long-term [financial] commitment."

The Pennovation Center hopes to remedy this with a 32-person lab available for customized leases (some as short as six months) for startups and inventors. These will come with all the typical wet lab gear: benches with view hoods, glass wash and sterilization centers, centrifuges, microscopy, and cell tissue culture and bioinstrumentation suites, in addition to safety measures like security systems, emergency eye wash and air change stations.

Senhert says the initial demand for the space is "robust" -- Penn is working now to "curate" which companies will be the best fit.

"Given that these are young companies, the more you can provide…this kind of sharing of basic services, that keeps the price more affordable and the [rental] terms shorter," says Anne Papageorge, Pennovation vice president of facilities and real estate development.

The Center will also provide programming, networking and training opportunities as a part of the package. This summer, they’re working on negotiating and executing license agreements for participating companies; the labs will be ready for occupancy in August.

The site offers two other lab spaces, adds Papageorge: a dry lab, and a currently empty lab building that Pennovation Works is holding with the intention of letting qualifying companies continue their work onsite in the future with a more customized, longer-term lease. The team hopes that as interest in the Center grows along with its companies, startups could "graduate" out of the shorter-term labs and into larger space. 

Writer: Alaina Mabaso
Sources: Paul Sehnert and Anne Papageorge, Pennovation Works
 

In Greek, "telesis" means "planned progress." Or as Maurice Hampton puts it, "'progress consciously planned and produced through intelligently directed effort.' Which characterizes how we get our work done at Telesis Therapeutics." 

Hampton is founder of the startup which is based at the University City Science Center's Port Incubator. The early-stage life sciences company is working to develop and license its first acquisition, "TTL-315," a promising cancer drug discovered at the Lankenau Institute for Medical Research.

"What I figured out is that molecules don't start out in [clinical trials.]," says Hampton. "They start out in the lab."

But the journey from lab to saving lives is a long, risky and expensive one. Telesis' role, he explains, is to identify, develop, de-risk and ultimately license the drug to a big pharmaceutical company that will conduct later-stage clinical trials, obtain FDA approval, take the medicine to market, and into the hands of patients in need. It's a process that takes years and millions of dollars, accelerated and made less risky by the work of the team at Telesis.

TTL-315 was developed to treat solid tumors such as pancreatic and triple negative breast cancers.

"Telesis Therapeutics preclinical, bench and animal, data for TTL-315 was published this past February 2016 in Oncotarget, a peer-reviewed medical journal focused on oncology," explains Hampton. "Preclinical efficacy results were positive: It worked! Preclinical toxicology reports were also positive -- a good sign -- and bode well for TTL-315's safety profile, a critical consideration in drug development."

The young company is pursuing a National Cancer Institute SBIR grant application and planning outreach to big pharma companies and other local funding sources to secure the necessary dollars to continue the preclinical research program. 

Hampton is ideally suited to the task: A serial entrepreneur, he has an MS and MBA, two years of medical school and years of international and domestic experience working at big pharma on blockbuster drugs including Prilosec  and the biologic Enbrel.

The lifesaving potential of TTL-315 is huge. The drug is initially aimed at pancreatic cancer, the fourth leading cause of cancer deaths in the U.S.  Eventually it could treat triple negative breast cancer,  lung and liver cancers. The potential payoff also could be huge. Current forecasts for the drug, at the time of launch, are estimated to be under $100 million in year one, growing to over $2 billion by the sixth year.

With the drug still in its infancy, Hampton takes the long view.

"At Telesis Therapeutics, we realize that this is not a sprint, it is an endurance run," he insists.

WRITER IN RESIDENCE is a partnership between the University City Science Center and Flying Kite Media that embeds a reporter on-site at 3711 Market Street. The resulting coverage will provide an inside look at the most intriguing companies, discoveries and technological innovations coming out of this essential Philadelphia institution.
 

"There are many different expressions of cooperation and mutual aid in Philadelphia, among very diverse groups of people," explains Caitlin Quigley of the Philadelphia Area Cooperative Alliance (PACA). Now, thanks to a $146,000 award from the national Knight Cities Challenge (check out our peek at the four Philly winners here), the organization hopes to expand interest in co-ops citywide.

PACA’s Knight-funded 20 Book Clubs, 20 Cooperative Businesses initiative aims to gather learning groups of six to 12 people from a variety of Philly neighborhoods. The organization will help guide the book clubs through a tailored process to master the building blocks of building a cooperatively-run business of any type, based on the community’s interests and needs.

So what exactly is a "co-op"?

A cooperative grocery store (like Philly’s Weavers Way or Mariposa), for example, "is a business you own with your neighbors," explains Quigley. "You make decisions about the products that are on the shelves, how the co-op should treat its workers; how the co-op should decide how to be in the community.”

The latter includes things like representation at events, education and outreach, and making donations.

"You and your fellow co-owners can decide how you want that business to serve you," she adds.

And while grocery stores might be the most prominent local example, PACA is a consortium of all kinds of co-ops across many industries. These range from banks to housing to community gardens, green space, or land trusts, or child-care or artist co-ops.

The 20 Book Clubs, 20 Cooperative Businesses project, operating on a year-long grant cycle from April 2016 to April 2017, will continue outreach this summer, with the goal of organizing project participants by September. Each group will meet twice a month for six months, with guidance from PACA staffers and volunteers, and a comprehensive curriculum of suggested learning materials, from books and comics to field trips and podcasts.

Author Dr. Jessica Gordon Nembhard, whose book Collective Courage is a major inspiration for the project, is collaborating with PACA on the study guide.

In March of next year, participating groups will convene at a large event that will include cooperative business pitches. Beyond that, PACA hopes to support interested groups in more intensive business planning, such as drafting articles of incorporation and writing bylaws.

"Not all of the groups that do the book clubs are going to necessarily decide to move onto this phase," says Quigley, but that’s ok. "Even if it doesn’t happen right now…They have a new set of tools and perspectives that they can bring to anything they do in their communities from then on." Ultimately, it’s about building "a strong movement around a just and inclusive economy, with all of these different sectors of cooperatives and their members."

Writer: Alaina Mabaso
Source: Caitlin Quigley, Philadelphia Area Cooperative Alliance

Entrepreneurs interested in "long -horizon" technologies -- those that require significant development and/or regulatory approvals in sectors such as healthcare, materials or energy -- have a new option for obtaining funding, expertise and other resources.
 
The University City Science Center's Phase 1 Ventures Program (P1V)  has emerged from stealth mode to widen its net and offer support to startups so new they might not even yet have names.
 
"Phase 1 Ventures serves the space in between our QED program (which provides resources to promising projects that are being developed within the academic setting) and our Port Business Incubators (which provide resources to startup companies that have already raised financing)," explains Science Center spokesperson Kristen Fitch. "P1V helps to 'road test' commercially relevant technologies outside the academic setting and to give them a chance to build management and raise funding."
 
Since P1V was soft-launched as a pilot in mid-2015, the program has supported these ventures, with several more expected to begin this year.
 

• BioSignal Analytics uses machine-learning techniques to interpret medical signals such as electrical brain signals. The technology is from Temple University. 
• LytPhage is developing a biotechnology that it hopes will replace chemical antibiotics in the fight against resistant bacteria. The technology is also from Temple.
• PolyCore Therapeutics is developing a new drug to manage the side effects of treating Parkinson's and other neurological diseases. The technology is from Drexel University and Rutgers University. 
• SDMI Inc., a startup formed by Dr. Chao Zhou from Lehigh University and Robert Michel, is developing a technology that will improve the speed and quality of eye exams.
• A team including Dr. Oscar Perez from Temple University and Science Center Entrepreneur-in-Residence Matt Handel is working on a treatment for psoriasis.
• A team including Dr. Joseph Freeman from Rutgers University and Science Center Entrepreneur-in-Residence Russell Secter is working on a technology for improving bone healing. 
• A team including Drs. Michael Zdilla and Stephanie Wunder from Temple University and Science Center Entrepreneur-in-Residence Grant Chapman is working on a technology to improve the performance of lithium ion batteries.

P1V initially provides up to $25,000 and a semi-customized package of resources including facilities, funding, management expertise, and professional services in areas such as intellectual property, regulations, reimbursement, market evaluation, grant preparation and financial management.
 
Once successful in securing non-dilutive financing (capital that does not affect its ownership), participants become eligible for Phase 1 financing from P1V -- typically $150,000. Phase 2, typically $300,000, will be available to teams that subsequently secure follow-on financing.
 
According to Fitch, PolyCore has become the first company to transition to Phase 1 and will receive up to $250,000 to further its development of pharmaceutical treatment for Parkinson’s symptoms. The company secured funding for its project -- through its collaboration with Drexel University -- from the Wallace H. Coulter Foundation. 
 
"There are plenty of options for the growing software and digital sector, but not enough opportunities for long-horizon technologies," said Science Center President Steven Tang in a statement. "These are the technologies that have historically been the cornerstone of our region’s economy."

WRITER IN RESIDENCE is a partnership between the University City Science Center and Flying Kite Media that embeds a reporter on-site at 3711 Market Street. The resulting coverage will provide an inside look at the most intriguing companies, discoveries and technological innovations coming out of this essential Philadelphia institution.
 

With limited access to screening, staggeringly few breast cancer patients in developing countries are diagnosed at the early stages of the disease, when it is most curable.
 
UE Lifesciences, a University City Science Center company, is working to meet that challenge with a low-cost, portable breast exam device.
 
Mihir Shah founded UELS in 2009 after several friends and family members were diagnosed with breast cancer. In April 2015, the FDA cleared the iBreastExam, a hand-held device that is painless, radiation-free and delivers accurate results in less than five minutes for less than $2 per exam. A few months later, UELS raised $3 million in equity funding. Now the company is using the capital to fabricate the device in Mumbai and scale it across India. Shah hopes to reach one million women there by the end of the year, though "even that would be a drop in the bucket," he says.
 
"iBreastExam is a game-changing technological breakthrough for countries and regions with rising breast cancer levels, most cases detected at late stages, and limited to no access to early detection for most women," explains the company on its website. "iBreastExam harnesses the power of innovative sensor technology, software computing and smartphone revolution, such that a doctor or any health-worker can offer objective and effective breast examinations, with ease and comfort."
 
The portable device is UELS's second invention. Its NoTouch Breast Scan, cleared by the FDA in 2012, is a contact-less and radiation-free screening tool, targeted at certain categories of women, including those at high risk for breast cancer.
 
Science Center spokeswoman Kristen Fitch calls UELS a poster child for the campus. Its core sensor technology was invented at Drexel University. The Science Center supported early prototyping through its QED program. UELS is also a graduate of the Center’s Digital Health Accelerator and continues to work out of the Center.

"They've been very flexible with the use of space, subsidized rent and great introductions to people," enthuses Shah.
 
Besides the equity funding, Shah reports that UELS has raised $1 million-plus in grant funding and $1.5 million in revenue.

"We are just getting started," he says. "We are looking to broaden our innovation portfolio and tap the huge unmet need for highly prevalent cancers in underserved markets. UELS is now a 30-person organization spread over two countries and growing fast."
 
WRITER IN RESIDENCE is a partnership between the University City Science Center and Flying Kite Media that embeds a reporter on-site at 3711 Market Street. The resulting coverage will provide an inside look at the most intriguing companies, discoveries and technological innovations coming out of this essential Philadelphia institution.
 

As high school seniors in their hometown of Vancouver, Miranda Wang and Jeanny Yao had some big questions -- and answers -- for a planet that produces enough plastic every year to circle itself in Saran wrap four times over.

Yao recently graduated from the University of Toronto and Wang is finishing her senior year at the University of Pennsylvania, majoring in Biology. Together they founded BioCellection. Now their team (which also includes Alexander Simafranca, Eric Friedman and Daniel Chapman) is the first undergraduate team ever to take the $30,000 grand prize at Wharton’s annual Business Plan Competition. And that's only the beginning: They also took home the Wharton Social Impact Prize, the Gloekner Undergraduate Award, the Michelson People’s Choice Award and the Committee Award for Most "Wow Factor." No other single team has ever taken five prizes in the competition.

Wang and Yao began studying riverside soil samples back in high school. They wanted to find out what the ecosystem itself might be doing to survive pollution from plastics. Traditional plastic products are made from fossil fuels, which come from carbon. Humans run on carbon, too -- our source is glucose.

"Could there be bacteria that have evolved with plastic chemicals as their carbon source?" Wang recalls wondering. "The answer is yes…Nature is very much evolving to recover itself. There is a solution in this biology, it just needs to be tapped into. Potentially this could be a large-scale commercial technology used to clean our drinking water."

Wang and Yao focused on how bacteria could be harnessed to break down potentially carcinogenic components of some plastics (like phthalates) that aren’t otherwise biodegradable. Their work won them the 2012 National Commercialization Award at Canada’s Sanofi BioGENEius Challenge and led to a popular 2013 TED talk.

In the labs at Penn, that work grew into BioCellection.

"Instead of tackling derivatives or additives in plastic, we’re [now] tackling the polymer of the plastic itself," explains Wang. "What if we can take this really big problem of the polymer, and try to solve it on a modular basis?"

BioCellection developed a way to engineer bacteria that produce an enzyme which, when combined with problem plastics in a proprietary portable chemical process, can convert that plastic into water and carbon dioxide. This patent-pending technology is still about two years away from the field, but its future application in plastic remediation at landfills, industrial sites, oceans and beaches could be tremendous, with annual revenue projected to reach $100 million by 2020.

A little further down the road in their business model, BioCellection hopes to launch a centralized processing plant that will use this enzyme to convert discarded plastics into a bio-surfactant necessary for textile manufacturing. With the help of collaborator Parley for the Oceans -- which is helping BioCellection connect to brands like Adidas that want to incorporate recycled plastic into their products -- the company hopes to sell this "upcycled" surfactant at $300/kg. It’s an estimated $42 billion market.

The issue of used plastics is a global problem: Because current recycling methods don’t generate enough revenue, over 90 percent of our cast-off plastics (even those going for recycling) end up in landfills, or incinerated, which compounds pollution. 

According to the company, "We can’t expect to change consumer habits overnight or integrate new materials immediately. It’s time to tackle the plastic pollution that currently exists, and that we’re continuing to produce, to save marine wildlife, keep the planet’s food chain intact, and protect human health."

Besides the $54,000 in total prize money from Wharton, BioCellection has earned $90,000 in grants and $240,000 in investment. The company is relocating to the San Jose BioCube in June 2016 for further development.

Writer: Alaina Mabaso
Source: Miranda Wang, BioCellection 

Philly ice cream connoisseurs have something to look forward to. Currently, if you want some top-rated Weckerly’s Ice Cream, you have to buy it by the pint (or sandwich) at a local cafe, food retailer or farmers' market, but now the company is gearing up to open its very own brick-and-mortar location on a bustling stretch of Girard Avenue in Fishtown.

Fronted by husband-and-wife team Jen and Andy Satinsky, Weckerly’s launched in late 2012 in West Philly’s Spruce Hill neighborhood. In 2014, the micro-creamery moved to Port Richmond’s Globe Dye Works.

"At that time, we really did want to open a retail shop eventually in West Philadelphia," says Andy. But the search proved difficult, so they broadened the hunt. With some help from New Kensington Community Development Corporation, they discovered a 350-square-foot shop at 9 West Girard Avenue, and knew it was the perfect place (they’ll still make their ice cream at Globe Dye Works).

"We definitely wanted a neighborhood," says Andy. "We wanted to be amongst families and homeowners, and people who engage in activities in their neighborhood."

Jen is an experienced pastry chef (her maiden name, Weckerle, inspired the company's moniker). A former bicycle mechanic, Andy eventually left his job to focus on the business full-time.

"[Jen] is the reason we make ice cream and have an ice cream company," he insists. "She’s the heartbeat of everything."

The company is known for unusual flavors such as buckwheat sour cherry and lemon verbena black raspberry, but "we do embrace the classics," he adds. "There’s a place for a vanilla ice cream made with grass-fed milk and cream and good-quality vanilla bean…that tastes like ice cream would have tasted 50 years ago."

Weckerly’s more adventurous combinations are inspired by the company’s mission to source seasonal ingredients from local farms. This is partly why the Satinskys need to grow their business with a retail location, rather than increasing wholesale production. With their own shop, they can stick with their model and showcase small batches of exclusive flavors -- perhaps only five gallons at a time.  

"There are aspects to the way we operate that don’t lend themselves well to a rapidly growing wholesale business," explains Andy, noting the difficulty of scaling up while still working exclusively with local farms.

The new Girard Avenue shop will be open year-round seven days a week, offering a selection of signature ice cream sandwiches and hand-dipped cups and cones, with six rotating ice cream flavors and two sorbets.

They couple isn't sure of an opening date yet, but hope to launch by late summer or early fall. Fans can follow along for the latest @Weckerlys on Twitter and Instagram, and on Facebook.

Writer: Alaina Mabaso
Source: Andy Satinsky, Weckerly’s 

As the Master of Social Work (MSW) supervisor at the University of Pennsylvania's Child Advocacy Clinic, Sara Schwartz quickly realized that the toughest dollars for hard-working social justice nonprofits to raise are general operating funds. She decided to combine her after-hours passion for jewelry-making with a business plan tailored to give back.

Schwartz founded Riot Alliance in early 2014, making custom jewelry and teaching community jewelry-making workshops. The company partners with a different nonprofit every quarter, donating 10 percent of sales towards the organization's operational costs, while also using online platforms and social media to promote the nonprofit and its events.

"After I got my MSW, I started thinking more seriously about starting an independent artist business that was connected to social justice from its inception," says Schwartz. She focuses on nonprofits working in areas such as immigrant rights; criminal justice advocacy and reform for youth and adults; economic justice; and youth leadership.

"I really wanted to focus on working with organizations in Philly who may have a more difficult time obtaining operational funding," versus grants earmarked for a certain program or purpose, she explains. The Riot Alliance money is available for crucial day-to-day expenses, supplies for community events, or stipends for community workers. For many of these smaller nonprofits, a small amount of money can go a long way.

Looking forward, Schwartz hopes to grow her model in several ways. She aims to make Philly arts fairs more accessible to those who can’t afford the cost of their own tables by purchasing a table herself and sharing it with an artisan from her current partner organization. She also wants to expand her community jewelry-making programming, and look into a stipend-based community or student internship to help her scale up production. Pursuing various independent arts grants and other funding will enable her to donate more in the future.

She also plans to expand her partnerships with other social justice and arts-based businesses via pop-up shops, like a recent one at W/N W/N Coffee Bar.

Riot Alliance's current partner is Juntos, a South Philly-based immigrant rights organization; in May, they'll begin working with Youth United for Change.  

Writer: Alaina Mabaso
Source: Sara Schwartz, Riot Alliance