life sciences : Innovation + Job News

The University City Science Center is looking for a few good women -- three to be exact -- as honorees for its Innovators Walk of Fame.

The Philadelphia institution is reinventing the pedestrian walkway along 37th Street between Market and Chestnut as a pocket park -- the Innovators Walk of Fame will be a key element.

"With a name like Innovators Walk of Fame, we thought it was imperative to come up with something more innovative than names etched on the sidewalk," explains Science Center Spokesperson Jeanne Mell. "Instead we’re going with an arrangement of cubes with metal panels etched with the honorees’ names."

The second group of honorees, to be announced in October, will celebrate female innovators with a connection to Greater Philadelphia.

"The Innovators Walk of Fame reflects the diversity of the local, regional and global communities in which the Science Center operates and innovates," says Science Center President Stephen S. Tang. "The face of innovation is varied and diverse, and to be relevant the Innovators Walk of Fame must reflect that spectrum."

The inaugural class of honorees comprised legacy innovators in the STEAM Categories:

* Britton Chance was a leader in biochemistry and biophysics focusing on the physics of electronics and radiation, and developing noninvasive optical devices used in medicine. 

* John W. Mauchly and J. Presper Eckert, Jr. created the Electronic Numerical Integrator and Computer (ENIAC), the first general-purpose electronic digital computer, developed at the University of Pennsylvania.

* Frank Piasecki was instrumental in the U.S. helicopter industry.

* Buckminster Fuller invented the geodesic dome. 

* Mathematician John Backus assembled and led the IBM team that developed Fortran, for years one of the pre-eminent programming systems.

* Lockheed Martin encourages its 4,800 employees in New Jersey and Pennsylvania to actively interact with the next generation of engineers and technologists by serving as local school advisors, extracurricular activity mentors and career role models for students.

Nominees may be alive or dead, and are not limited by industry or type of innovation. According to the Science Center, successful nominations will complete this sentence: "If not for this woman’s innovation, the world would be a lesser place because..."

The deadline is June 15.

Source: Jeanne Mell, University City Science Center
Writer: Elise Vider

Ten early-stage companies in Greater Philadelphia are at work on innovative projects, and they're getting a boost from $2 million in new investments from Ben Franklin Technology Partners of Southeastern Pennsylvania. 

Atrin Pharmaceutical is a Bucks County biopharmaceutical firm that centers its research on the treatment of cancers lacking effective therapies. Its technology will advance drug development for the treatment of solid tumors including breast, pancreatic, lung, ovarian and colon cancers.

Decision Simulation in Chester County is the creator of DecisionSim, a simulation-based learning platform that enhances decision-making by allowing organizations to easily create assessment, education and training programs. Leveraging adult learning and gaming concepts, DecisionSim allows custom learning experiences to be developed while evaluating the decisions of learners, and collects valuable objective behavioral data to allow for a greater understanding of decision-making.

H2Odegree (H2O) in Bucks County is a manufacturer of wireless sensors and Software as a Service (SaaS) that provides solutions for measuring, controlling and billing utility costs in apartments, allowing landlords to improve their overall financial performance. The company’s target market is multi-family housing customers who use the company’s products and services for tenant billing and energy conservation related to water, electric, gas, btus and thermostat controls. H2O has over 38,000 sensors installed in 13,000 apartments in over 130 properties throughout North America.

MilkCrate in Philadelphia engages and rewards users who want to live their values by providing sponsored civic and commercial opportunities related to sustainably. Its app serves as a central digital hub for municipalities, businesses and organizations to reach conscientious consumers with relevant and tailored information.

Philadelphia’s Pico is a real-time engagement tool for brands, allowing them to engage with fans during events through the fans' pictures. All fans' pictures are automatically uploaded to the brand’s Facebook Page. Using Pico’s auto-tagging abilities, a real bond between the fan and brand is created.

In Bucks County, PrescribeWell is a new Platform-as-a-Service that enables physicians, healthcare providers and integrated health systems to seamlessly implement a turnkey, self-branded prevention, wellness and obesity intervention business in their existing practice. Customers license the company’s "white label" solution as their own, enabling them to generate significant new revenue streams that leverage the changes in healthcare reimbursement policy for physicians in preventive medicine.

In Philadelphia, RistCall helps hospitals and skilled nursing facilities improve patient safety and satisfaction scores by updating traditional wall-mounted nurse-call buttons with wearable technology devices. RistCall currently focuses on reducing patient falls and improving hospital/patient satisfaction.

Philadelphia’s Textizen provides mobile technologies for public engagement. The company makes it easy for government, organizations and companies to connect with people on the device they use most -- their mobile phone. The platform sends, receives and analyzes text messages. Administrators can click one button instead of making 10 or 10,000 phone calls, and use real-time dashboards to inform policy changes or deliver better customer service.

TowerView Health in Philadelphia helps chronically ill patients manage complex medication regimens. Patients using TowerView’s service receive pre-filled medication trays that insert into a connected pillbox, facilitating complex regimens with preformed ease -- its akin to a single-serve coffee machine. The connected pillbox senses when patients forget medication doses and sends automated text message or phone reminders to patients and their loved ones.

Viridity Energy in Philadelphia, a software technology company focused on total energy management, has a software and technology platform that allows commercial and industrial users to identify inherent load flexibility in their operations and monetize it. The company says its"“software turns energy profiles into financial returns"” transforming how energy customers interact proactively and productively with the electric grid.

Source: BFTP/SEP
Writer: Elise Vider

When we think of the human element in medicine, we might think of the doctor who interacts with the patient in need of treatment. But thanks to a burgeoning revolution in the biopharmaceutical industry, there are thousands of other face-to-face meetings that need to happen long before any drug even reaches a trial, let alone the market.

In the biotech industry, these connections are called "partnering," and it’s a vital piece of the Biotechnology Industry Organization's (BIO) 2015 BIO International Convention, coming to the Pennsylvania Convention Center June 15-18. The Washington, D.C.-based BIO is the world’s largest trade association for biotech companies, academic institutions and government science centers, and organizers say the convention will draw about 15,000 people from 30 countries (about one third of attendees will come from outside the U.S.).

"The 2015 BIO International Convention is where the global biotech community meets," explains BIO Director of Partnering Sougato Das.

Das calls Partnering "biotech-pharma speed-dating," and this year, it’s happening thanks to BIO’s new propriety software system, One-on-One Partnering, developed by BIO and INOVA.

The BIO convention will be packed with CEOs and other executives from biotech companies all over the world, working to advance everything from medicine and human health to industrial, environmental and agricultural technology, as well as biomanufacturing, genomics, nanotechnology and more. Picture an area the size of a football field, outfitted with hundreds of cubicles for face-to-face meetings. 

That's where the One-on-One platform comes in. Companies or institutions that want to pitch their promising biotech advances can use the software to connect with companies looking to invest in and/or develop and market their innovations. The system allows participants to enter their companies' details, their individual conference schedules, and invitations to the people they need to meet. The software automates the rest, generating a schedule for everyone that maximizes the crucial face-to-face time that powers the modern industry.

During the June conference, organizers estimate that over 29,000 meetings will take place among the 6,000 or so attendees who will participate on the Partnering platform. That means over 1,100 different meetings per hour at the conference’s peak times.  

Why are these meetings important? According to Das, to understand that you have to understand how the biotech and biopharmaceutical industries have changed since the 1950s and 60s. Back then, the massive companies of today like Merck and Pfizer were getting started, employing tens of thousands of in-house scientists and researchers who developed relatively simple drugs with mass-market applications.

Today, what Das dubs the "low-hanging fruit" of new drug development is gone and researchers are working on more complicated molecules, compounds and drugs for more targeted consumer audiences. Instead of discovering and developing new drugs or other biotech innovations in-house, throngs of scientists, researchers, academics, investors and businesses participate in a much broader-based search for the next big breakthrough. But that takes meetings -- lots of meetings.

"There’s more variety out there," says Das. "All they have to do is meet with these people who have these new biotechnology innovations out there and say, show me what you got -- let’s see if it’s a fit for my company."

Writer: Alaina Mabaso
Source: Sougato Das, Biotechnology Industry Organization

A Penn State team has launched a crowdfunding campaign to support its promising research on brain repair.

"Our revolutionary technology holds promise as a potential treatment for many brain injuries and disorders," explains Gong Chen, a biology professor and the Verne M. Willaman Chair in Life Sciences, who heads the research. "We recently discovered a way to transform one type of a patient's own brain cells -- called glial cells -- into healthy, functioning nerve cells that can replace those damaged by Alzheimer's disease, Parkinson's disease, brain trauma, spinal-cord trauma or stroke. For the first time in history, our revolutionary technology now can reverse glial scars back into functional neural tissue inside the brain."

According to an article written by Penn State spokeswoman Barbara Kennedy and originally published in the Centre Daily Times, Chen’s team has published research describing its success: "Even in very old mice with Alzheimer’s disease, [they were] able to regenerate many functional neurons from the internal glial cells of these mice and to replenish the lost neurons in the brains of the mice. This research raises the hope that neural-replacement therapy might someday help human patients."

The new month-long crowdfunding campaign has a $50,000 goal and ends at the end of April. The money will allow the lab to purchase critical equipment and materials, and to proceed more quickly to clinical trials. 

"It will take at least an estimated $1 million per year to hire highly skilled people and to carry out vital tests on several specific disorders," says Chen. "With [funding] we can move our lab research to human clinical trials much faster, perhaps shortening the delivery of drug therapy to patients from 10 years to five years."

Source: Barbara Kennedy, Penn State University
Writer: Elise Vider

The Women in Natural Sciences (WINS) program at Drexel’s Academy of Natural Sciences has been going strong for 32 years, and now a special grant from the U.S. Department of State’s Museums Connect program is allowing a team of 15 Philly public high school girls to collaborate with 15 girls from Mongolia on a globe-spanning project.

For the last several months, the teens have been using online courses, Facebook and Skype to study climate change and its cultural impact. Then last week, four girls from the Mongolian side of the project, administered through the National Museum of Mongolia’s ROOTS program, had a whirlwind visit to Philadelphia. This July, five public high school girls from Philadelphia will reciprocate with their own two-week trip to Ulaanbaatar, the capital of Mongolia.

The climate change focus of the youth program is three-pronged, explains WINS manager Betsy Payne: "One is water, one is food, one is the cultural repercussions."

Currently, there are 60 girls in the WINS program citywide, but the Museums Connect dollars (administered by the American Alliance of Museums) allowed for just fifteen Mongolian girls and fifteen Philly girls. WINS sophomores and juniors were invited to apply for the program, and were selected based on a range of criteria.

"Even though it’s a one-year program, we’re hoping it has repercussions where they might be able to do more in the near future," says Payne of the age group she decided to target and applicants' dedication to the program’s offerings. The Academy was also "looking for the girls who hadn’t had other opportunities of major travel." 

The lucky travelers are George Washington Carver High School of Engineering and Science sophomore Faatimat Sylla; junior Geré Johnson from the Mathematics, Civics and Sciences Charter School of Philadelphia; Harleen Gonzalez, a sophomore at Central High School; Academy at Palumbo sophomore Linda Gutierrez, and Philadelphia High School for Girls junior Ti’anna Cooper.

The project’s capstone, for both teams of girls, will be a final display based on what they’ve learned in their year of cross-continental collaboration. The form it will take will be up to the students, as long as it deals with climate change and cultural exchange: a short play, a museum activity, a presentation of specimens or something else the young women devise.  

The Mongolian students' U.S. trip was packed with classroom visits and science as well as some historic sight-seeing in Old City, cheesesteaks on South Street, a Lancaster farm visit, a tour of Washington, D.C. that included the Smithsonian Natural History Museum, and even some good old-fashioned retail therapy at the King of Prussia Mall.

By early fall, the two intercontinental teams will develop lessons and presentations about climate change that will be incorporated into the public programming at the Academy of Natural Sciences and the National Museum of Mongolia.

Writer: Alaina Mabaso
Source: Betsy Payne, The Academy of Natural Sciences
 

In the sounds-like-science-fiction department comes BioBots, a Philadelphia startup developing high-resolution, desktop 3D printers that generate living tissue.

"BioBots is like a 3D printer, but instead of using plastic filament to create 3D structures, it uses mixtures of biocompatible materials (like collagen) and living cells to create 3D tissues," explains CEO Danny Cabrera. "The finished product that comes out of the BioBot is alive."

The first-generation BioBots 1 printer can generate a dozen different cell types. 
  
With over 120,000 patients in the United States on organ-transfer waiting lists, building replacement organs is a long-term goal for the company. For now, the printers are primarily used for research.

"Biofabrication technology is definitely becoming more and more accessible in functionality, ease of use and cost, and that is going to greatly accelerate the pace of development," says Cabrera. "We are currently focusing on making the best research tool for our customers, taking structures out of lab note books and onto lab benches. It’s only a matter of time before those same structures start leaking out of the lab and into the clinic." 

Co-founder Ricardo Solorzano started working on printing 3D tissues -- and built the first prototype -- in his University of Pennsylvania dorm room. In August, he and Penn classmates Cabrera and Sohaib Hashmi launched the company. The startup initially grew at the DreamIt Health incubator and recently received funding from Ben Franklin Technology Partners of Southeastern Pennsylvania. 

BiotBots is also opening a seed round of funding; actively promoting its beta program; offering testers a bioprinter and support for $5,000; and recruiting for its R&D team.

"The BioBot 1 is exciting, but it’s definitely not all we have up our sleeves," insists Cabrera. "Look out for a radical change in a few healthcare-related industries and new industries being created by our technology."

Source: Danny Cabrera, BioBots
Writer: Elise Vider
 

The University of Pennsylvania's new Penn Center for Innovation, described as "a dedicated, one-stop shop for commercial partnering with Penn," has been awarded a National Science Foundation (NSF) grant to foster entrepreneurship and commercialization.

Under the three-year grant, Penn is launching the Penn I-Corps Site, a new business accelerator, in collaboration with Wharton's Mack Institute for Innovation Management, Penn Medicine’s Center for Healthcare Innovation, Ben Franklin Technology Partners of Southeastern Pennsylvania (BFTP/SEP) and the City of Philadelphia.

In its grant announcement, Penn said the Penn I-Corps Site will "support translation of research areas into the marketplace by providing educational programming, financial advice and strategic guidance."

The accelerator gets underway this summer with 30 faculty-student interdisciplinary teams creating commercialization plans for their early-stage technology. The goal is to help the teams launch new ventures by the end of 2015 with well-developed business models that position them to apply for further NSF funding.

The Summer Accelerator Program is open to Penn faculty and students as well as local entrepreneurs. An organizational meeting is set for 4:30 p.m. Tuesday, February 24 at the World Café Live (3025 Walnut St., Philadelphia).

A committee comprised of investors, experienced entrepreneurs and industry experts will select the participants; the program will launch in May. The teams will have access to lectures and hands-on activities, guidance on developing and testing their business models, up to $2,500 in NSF funding for prototyping and other expenses, and connections to an extensive entrepreneurial network.

"We’re excited to work together to build a network of mentors and advisors to help the teams gain real-world experience in bringing technology from the lab to the market," explains RoseAnn Rosenthal, president and CEO of BFTP/SEP, "and to build a pipeline of investable enterprises that can creative economic value in our region."

Source: The Penn Center for Innovation
Writer: Elise Vider

 

Two health care IT companies and a biotech startup are the newest members of the entrepreneurial community at the University City Science Center’s Port business incubator. 

Denovo Health (de novo is Latin for a new beginning) is an engagement platform targeting chronic diseases that have a high annual cost per patient and where even marginal improvements in patient engagement drive significant health and financial benefits.

According to their website, the company incorporates "design thinking with behavioral psychology and [uses] advanced technologies to make prescribed activity easy, enjoyable and rewarding." Using mobile apps, digital and physical world interactions and behavioral change tactics, Denovo’s products target glaucoma, rheumatoid arthritis, multiple sclerosis and diabetes, assisting users with tracking their medication, monitoring their condition and communicating with care providers. Competitive game dynamics, rewards and social reinforcement are incorporated to boost compliance. 

Smart Activities of Daily Living (Smart ADL) is developing a digital health technology called Smart Cup that enables patients and clinicians to unobtrusively record and monitor fluid intake for effective clinical and self-care management.
 
Oncoceutics, Inc. is a drug discovery and development company targeting the most potent natural suppressor pathways in human cancer. The company’s lead compound is ONC201, a novel small molecule that promises strong anti-cancer activity in the most challenging indications in oncology. 

Oncoceutics' application to initiate clinical trials with ONC201 was accepted by the FDA in February 2014 and a series of clinical studies at leading cancer centers is being activated. Oncoceutics has development ties with Penn State and the University of Pennsylvania.
 
Source: University City Science Center
Writer: Elise Vider

While teaching yoga and aerobics at Interim House, a recovery center for women overcoming addiction and other mental health issues -- many of whom had been incarcerated -- Kristin Gavin noticed that her classes weren’t reaching everyone.

"I surveyed them and asked, would you ride a bike?" recalls Gavin. Many of the women, including those who wouldn’t come to yoga or aerobics, said yes.

What was the difference?

"Women said, 'it’s fun,' 'it’s exercise,' and ‘I want to get out of the house,'" she explains.

So Gavin, who came to Philadelphia in 2007 to earn her Masters degree from Temple University in Exercise and Sport Psychology, launched the Center City-based Gearing Up with five bicycles in 2009. In December, the program nabbed a $40,000 grant from the GlaxoSmithKline IMPACT Awards.

Part of what spurred Gavin to create a community cycling program for formerly incarcerated women was realizing what a challenge even a relatively short jail term could be for a woman’s health. Many of her students talked about the problem of weight gain. One said she had gained 80 pounds while incarcerated for six months.

In 2011, Gearing Up's program expanded to serve not just women outside the walls, but those still residing in Philadelphia County's Riverside Correctional Facility, offering three indoor spin classes per week for inmates. Those who complete 18 sessions in eight weeks are invited to join the outside Gearing Up program upon their release.

By tracking the health of Riverside participants, Gavin learned that women who had an 80 percent class attendance rate maintained their weight throughout their incarceration.

But cycling isn’t just about the number on the scale. Since founding Gearing Up, Gavin has been surprised by all the ways this activity has helped women re-integrate into physically and socially healthy lives.

For women emerging from correctional facilities, Gearing Up has four partner programs in Philly: Interim House, CHANCES, University City's Kirkbride Center and Gaudenzia Washington House. The organization leads two to three group bike rides per week for their clients, who track their miles until they reach 100. At that point, members graduate from the program, receiving a refurbished bike of their own (along with a lock, flat-changing kit, helmet and other gear).

"It has this whole other social component to it that wasn’t as palpable with an aerobics class or a yoga class," insists Gavin. And especially for the many women coming from repressive or abusive environments, the exercise was a great mood elevator and change of scenery.

"Women say, 'The fresh air feels so good in my face,'" she explains. They enjoy getting out in the community, seeing new places and "developing relationships with people in a very different way, a very kinesthetic way, and those are very normalizing experiences."

"Our focus has been going deeper," Gavin says of how the GSK dollars will help Gearing Up (a first-time applicant for the grant). That means extending services to the 40 women the program serves at any given time. The money will help provide increased support through volunteers and staff, even after participants’ graduation from the program, ensuring riders can make their skills on the road a permanent part of an independent life.

Writer: Alaina Mabaso
Source: Kristin Gavin, Gearing Up

A version of this story originally appeared in our sister publication Keystone Edge.

Independence Blue Cross, through its Center for Health Care Innovation, and Drexel University are embarking on a new research collaboration aimed at improving the delivery of health care and controlling costs. 

Researchers are currently evaluating a number of areas for study including:

• Identifying Independence members at risk for hospitalization and re-hospitalization, as well as identifying members who would benefit from Independence’s chronic disease outreach programs.
• Applying machine learning techniques to unstructured data, such as notes from members’ interactions with doctors and other health professionals, to predict future health problems or customer service issues.
• Evaluating health interventions that can reduce the number of avoidable emergency department visits.
• Improving the detection of fraudulent claims, predicting when fraud is likely to occur and developing strategies to help members protect their medical identity.

Though the specific research projects won’t be identified for a few months, they will "involve new ways to use data to improve health and lower costs," explains Independence spokeswoman Ruth Stoolman. 

"Each project will have a principal investigator designated from Drexel and a corresponding lead investigator from Independence," she adds. "The analyses will take place at Independence and at Drexel (all appropriate HIPAA [patient privacy] protections are in place). Some projects may also involve outreach and intervention with members and/or providers. Those interventions may be done by Drexel or Independence depending on the nature of the project and the outreach."
 
"We're already seeing some impressive early results from informatics projects we’ve designed, as well other research partnerships we’ve initiated, to improve our members’ health," said Somesh Nigam, Independence’s senior vice president and chief informatics officer, in a statement. "We’re going to see tremendous growth in machine learning and predictive analytics over the next few years, and it’s very exciting for Independence to be at the center of that work."  

Independence and Drexel also teamed up in 2012 to create a business analytics certificate program for Independence associates through the Krall Center for Corporate and Executive Education in the university's LeBow College of Business. Now in its third year, the program focuses on developing a deeper understanding of how to make databased decisions and teaches analytic techniques for identifying opportunities to enhance health care quality and services.

Source: Ruth Stoolman, Independence Blue Cross
Writer: Elise Vider
 

Part of a healthy society includes the arts, and part of an individual life well-lived includes the arts, says Drexel University Department of Creative Arts Therapy chair Dr. Sherry Goodill. So why shouldn't the modern healthcare system include them as well?

That’s part of the goal of Drexel’s new Parkway Health and Wellness Clinic, a 23,000 square-foot facility that opened in November on the second floor of the Three Parkway Building at 1601 Cherry Street. It’s a new center for patient care and research through the university’s College of Nursing and Health Professions.

"We had a vision to develop a clinical practice integrated with the research that we do here," explains Dr. Sue Smith, chair of Drexel’s Department of Health Systems & Sciences Research.

The Clinic, a teaching as well as a treatment and research facility, is open to a wide range of patients with physical and behavioral health issues. They offer primary care services (focusing on women's health and occupational therapy), physical therapy for athletes and those with medical conditions, and more. 

According to Dr. Smith, Drexel’s Creative Arts Therapy PhD program is unique in its field. She also asserts that creative arts therapy is "an up and coming area that is not as well developed as some other health divisions."

Dance, music, or the literary and visual arts can have a major positive impact on patients with emotional or behavioral challenges. As with any new health discipline, researchers are working on building the evidence for what those exact mechanisms of change are, explains Dr. Elizabeth Templeton, a clinical assistant professor and coordinator of Creative Arts Therapies' clinical services.

"Arts themselves can be inherently therapeutic and healing," says Dr. Goodill. "What we do in creative arts therapies is harness that…for individual treatment goals."

Dr. Templeton explains how something like dance-based therapy works. A typical early session is similar to a talk therapy model, but builds to something more holistic.

"It’s an awkward transition: communication through words to communicating through movement," she says. But since movement can express things that can’t be expressed in language, "How do we create a relationship through movement?"

Ultimately, integrating elements of movement and dance helps the patient "experience the body in new ways," with new methods of sensation and feeling grounded that "reverberate" through a person’s mind and feelings, to effect change in his or her behavior.

Examples of this include body stances that underscore healthy boundaries and standing up to others, or movement and balance exercises that help the patient revise crippling black-and-white ways of thinking. Exploring these ideas through the body, and not just through conversation, "can be translated to a conceptual, reframing level" that improves the patient’s daily life, says Dr. Templeton.

To learn more about services available at the Parkway Health and Wellness Clinic, call 215-553-7012. 

Writer: Alaina Mabaso
Sources: Dr. Sue Smith, Dr. Sharon Goodill, and Dr. Elizabeth Templeton, Drexel University Department of Creative Arts Therapy
 

Like a little water science with that happy hour beverage? The Academy of Natural Sciences of Drexel University is re-launching a "science café" program, previously held at the Cherry Street Tavern, at Old City’s National Mechanics.

The new monthly program is called Tapping Our Watershed. The first presenter (6 p.m. Monday, November 17) is Carol Collier, the Academy's senior advisor for watershed management and policy and director of Drexel's Environmental Studies and Sustainability program. These "happy-hour-style lectures" on the science of local rivers will happen on the third Monday of each month and be similar to the existing Science on Tap events run through the Academy and other local partners on the second Monday of the month.

Collier’s presentation is called "The Future of the Delaware River Basin: Why We Need to Think Holistically." It’ll be a chance to learn about what’s stressing our modern waterways, and what we can do to help.

"What I’m hoping for mostly is for people who are experts to talk about these issues in a supportive environment…and for those who are less experienced to realize there is so much work being done," says Meghan O’Donnell, a staff scientist at the Academy who manages the Tapping Our Watershed seminars. "I think that a lot of this goes under the radar for people." 

O’Donnell coordinates field research for the Delaware River Watershed Initiative, funded by a $35 million commitment from the William Penn Foundation. It’s a "really expansive" project, she explains, monitoring the waters and ecosystems flowing from the headwaters of the Delaware River, up in the Poconos, all the way to Philadelphia. Partnerships with about 40 other organizations help to monitor 35 different sites four times a year.

"We’re pretty much on the go all the time," she adds. "We just finished our algae and fish surveys, and now we’re moving on to fall chemistry."

O’Donnell appreciated the original Cherry Street venue but is looking forward to the facilities at National Mechanics, with its larger space and A.V. accoutrements. She hopes the expert commentary in the informal setting will help "people to feel relaxed and grab a beer after work, and still keep themselves informed on what’s going on in the watershed."

Writer: Alaina Mabaso
Source: Meghan O’Donnell, The Academy of Natural Sciences
 

Four early-stage companies, including one making its first foray into the U.S. market, are settling in at the University City Science Center's Port Business Incubator. 

CETICS Healthcare Technologies is a medical device company based in Germany. With its analysis technology and digitalization of sample profiles, the company's products drastically simplify how in-vitro diagnostics are used, opening new application areas in quality control, chemical stability testing, toxicology, and process optimization and control.

In Philadelphia, the company is launching a new product for genotoxicity testing. The TOXXs Analyzer is an automated method for fast quantification of DNA strand breaks and DNA repair capacities. 
 
In the longer term, CETICS is developing a new generation of breakthrough in-vitro diagnostic products known as "Spectral Biomarkers" that can provide early, non-invasive diagnoses of Alzheimer Disease, prostate cancer and liver fibrosis.

HaRo Pharmaceutical, another new Port company, is conducting research and development focused on the treatment of high-risk neuroblastoma, funded by the National Cancer Institute (NCI). HaRo was the only small molecule therapeutic company -- out of 75 startups nationwide -- admitted to the Innovation Corps Team Training Pilot Program (ICORPS),  an NCI/National Institutes of Health-sponsored intensive commercial development course.
 
Hyalo Technologies is a biotech and pharmaceutical company developing an innovative nanotechnology drug delivery system that promises to drastically reduce systemic side effects and increase patient compliance. Potential applications include cancer, pain management, wound healing and dermatology.

Legal Science Partners (LSP), spun out of Temple University's Beasley School of Law in 2013, builds tools for the legal profession. LSP's knowledge management platform, The Monocle, allows easy, low-cost access to legal information across jurisdictions and topics. Meanwhile, products such as LawAtlas.org and Workbench convert unstructured legal text into structured question-and-answer formats.

LSP is currently building custom platforms in particular areas of law such as Prescription Drug Overdose Prevention Laws for the National Institute for Drug Abuse and Everytown for Gun Safety, and is planning to release a prototype in the coming weeks of its 50StatUS, which will include pay-per-use statutory data in the business law sector.

Source: Kristen Fitch, University City Science Center
Writer: Elise Vider

The University City Science Center has partnered with Flying Kite to showcase innovation in Greater Philadelphia.
 

Flying Kite has twice shared the story of Invisible Sentinel, a local life sciences firm that develops low-cost and user-friendly diagnostic tools for the food and beverage industries.
 
The company's most recent breakout success was the result of a partnership with Sonoma County's Jackson Family Wines -- a novel and fast-acting product known as Veriflow BRETT was developed as a way to detect a yeast strain that commonly affects both the taste and aroma of wine.  
 
According to Invisible Sentinel co-founder Ben Pascal, that technology has since been adopted by large sectors of the wine industry.

"We've been so successful in the food safety [sector]," says Pascal. "And so we started asking ourselves, 'What other groups have the same types of problems with these organisms that can affect quality?' And naturally, we came to beer."
 
More specifically, they came to beloved local brewers Victory Brewing Company. The heads of the two companies met during a dinner party, and when Pascal and his business partner Nick Siciliano began talking to Victory's Bill Covaleski about the success of their Veriflow BRETT technology, "I think it got his wheels turning," recalls Pascal.  
 
Following a few months' worth of meetings with Victory's brewers and quality control team, a decision was reached to partner on the development of a new rapid molecular diagnostic tool, Veriflow brewPAL, that will quickly detect two types of bacteria that can spoil the taste of beer, leading to spillage at brewing companies that can't afford to lose inventory.
 
"There isn't any [similar] technology that exists today that's easy to use, and that's accurate and cost-effective," explains Pascal. "And with a partner like Victory behind us, I think this product is really going to be a paradigm shift, and a big game-changer in the industry."
 
Writer: Dan Eldridge
Source: Ben Pascal, Invisible Sentinel 
 

The annual Philadelphia Honey Festival, a celebration of the importance of bees and the honey they produce, has been in existence for just five years now. But to hear Suzanne Matlock of the Philadelphia Beekeepers Guild explain it, the three-day festival -- running September 5 to 7 at three historic locations throughout the city -- can trace its genesis back to Christmas Day 1810. That was the day Reverend Lorenzo Lorraine Langstroth was born at 106 S. Front Street.
 
Widely known as the "Father of American Beekeeping," Langstroth is the man responsible for inventing the Langstroth bee hive. Consisting of movable frames and resembling a stout wooden cabinet, the Langstroth is still considered the definitive beehive for keepers worldwide. So important was his contribution to beekeeping that on the 200th anniversary of his birth, a historical marker noting his accomplishments was raised outside his former Front Street home.  
 
The first annual Philadelphia Honey Festival was also celebrated that year, largely to honor Langstroth's memory and his significant impact on the craft. Only 500 people took part.

But in the seasons since, the event has evolved into a family-friendly educational and cultural celebration promoting urban beekeeping. It aims to "increase awareness of the importance of bees to [the] environment" and "the impact of local honey on our economy," according to a release. Last year, over 2,300 bee-curious locals showed up. 
 
Organized by the Beekeepers Guild and hosted at Bartram's Garden, the Wagner Free Institute of Science and Wyck Historic House, the festival's free events range from bee bearding presentations and open beehive viewings to a honey-themed happy hour and honey extraction demonstrations.

For a complete schedule, click here. (Don't miss the Beekeeping 100 panel on September 7.)
 
Writer: Dan Eldridge
Source: Suzanne Matlock, Philadelphia Beekeepers Guild