The proliferation, enthusiasm and strength of the mostly first-generation startups throughout Greater Philadelphia make the region ripe for venture capitalists. With roughly $400 million and 100 financings annually. What's more, established funds (Quaker BioVentures) and networks (Greater Philadelphia Alliance for Capital and Technologies) are being joined by newer funds like Mentor Tech Ventures out of the University of Pennsylvania, and even Comcast has its own venture and seed-stage funds. With a particular focus on cloud computing, software as a service, biotech and energy startups, the region is well-positioned to be among the East Coast's leaders in VC and startup growth.